Improving patient outcomes in pulmonary hypertension

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Improving patient outcomes in pulmonary hypertension.

Affiliations: Dept of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, Bologna, Italy. Dept of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA. Division of Pulmonary and Critical Care Medicine, University of California, San Diego, CA, USA. Hôpital Universitaire de Bicêtre, Université Paris-Sud, Le Kremlin Bicêtre, F...

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Ambrisentan is an endothelin receptor antagonist (ERA) that was recently approved for treatment of pulmonary arterial hypertension (PAH). Endothelin (ET) is a potent vasoconstrictor with mitogenic, hypertrophic and pro-inflammatory properties that is upregulated in pulmonary hypertensive diseases. The biologic effects of ET are mediated by 2 cell surface receptors termed ET(A) and ET(B). ET(A) ...

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Evaluation of Pulmonary Hypertension In First Degree Relatives Of Patients With Primary Pulmonary Hypertension

Background: Pulmonary hypertension (PH) was defined for the first time in 1951 as primary pulmonary hypertension (PPH). Some studies emphasized on the role of genetics in the development of pulmonary hypertension in family members of affected patients. So, in this study we evaluated the prevalence of pulmonary hypertension in first degree family of patients with documented PPH. Methods: In thi...

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Improving survival in pulmonary arterial hypertension.

M ore than 50 yrs ago, DRESDALE et al. [1] reported a series of 39 patients with unexplained pulmonary hypertension and coined the term ‘‘primary pulmonary hypertension’’ to describe the condition, a term that has been revised to ‘‘idiopathic pulmonary arterial hypertension’’ in the most recent classification [2]. Idiopathic pulmonary arterial hypertension is a disease of the small pulmonary ar...

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ژورنال

عنوان ژورنال: European Respiratory Review

سال: 2015

ISSN: 0905-9180,1600-0617

DOI: 10.1183/16000617.0064-2015